What does rhabdomyolysis refer to?

Rhabdomyolysis refers specifically to the breakdown of skeletal muscle tissue leading to the release of muscle fiber contents, including myoglobin, into the bloodstream. This sudden necrosis, or death of muscle fibers, can result from various factors such as trauma, excessive exercise, or drug use. The release of myoglobin into the bloodstream can result in serious complications, including kidney damage. This pathophysiological process is critical to understand, especially since timely recognition and treatment can prevent complications like acute kidney injury.

Chronic muscle inflammation, muscle weakness, and joint swelling are not characteristics of rhabdomyolysis; instead, they refer to different conditions or situations that may affect muscle or joint health. Thus, the correct interpretation of rhabdomyolysis is centered on the acute and damaging aspect of muscle necrosis.